endstream endobj startxref 0000093244 00000 n You cannot usually choose which vaccine you have. z(2$bW*; ! One dose (0.5 ml) contains: Vaccine Maker Halts Trial Following Unexplained Illness in Volunteer, Details Emerge on Unexplained Illness in AstraZeneca COVID Vaccine Trial, A Study of a Candidate COVID-19 Vaccine (COV001), New Vaxzevria Data Further Support its Use as Third Dose Booster, Vaxzevria Significantly Boosted Antibody Levels Against Omicron, Vaxzevria is Highly Effective After One Dose Against Severe Disease or Hospitalisation Caused by Beta and Delta Variants of Concern, Vaxzevria Induced Immunity for at Least One Year Following a Single Dose and Strong Immune Responses Following Either a Late Second Dose or a Third Dose, COVID-19 Vaccine AstraZeneca Effective Against Delta (Indian) Variant, AstraZeneca COVID-19 Vaccine Vaxzevria Authorised for Emergency Use in Japan, AZD1222 US Phase III Primary Analysis Confirms Safety and Efficacy, AZD1222 US Phase III trial Met Primary Efficacy Endpoint in Preventing COVID-19 at Interim Analysis, UK and EU Regulatory Agencies Confirm COVID-19 Vaccine AstraZeneca is Safe and Effective, Update on the Safety of COVID-19 Vaccine AstraZeneca, AstraZeneca Advances Mass Global Rollout of COVID-19 Vaccine Through COVAX, AstraZeneca COVID-19 Vaccine Authorised for Emergency Use by the World Health Organization, COVID-19 Vaccine AstraZeneca Confirms 100% Protection Against Severe Disease, Hospitalisation and Death in the Primary Analysis of Phase III Trials, COVID-19 Vaccine AstraZeneca Authorised for Use in the EU, COVID-19 Vaccine AstraZeneca Recommended for Use in the EU, Serum Institute of India Obtains Emergency Use Authorisation in India for AstraZenecas COVID-19 Vaccine, AstraZenecas COVID-19 Vaccine Authorised for Emergency Supply in the UK, AZD1222 Oxford Phase III Trials Interim Analysis Results Published in The Lancet, AZD1222 Vaccine Met Primary Efficacy Endpoint in Preventing COVID-19, FDA Authorises Restart of the COVID-19 AZD1222 Vaccine US Phase III Trial, COVID-19 Vaccine AZD1222 Clinical Trial Resumed in Japan, Follows Restart of Trials in the UK, Brazil, South Africa and India, COVID-19 Vaccine AZD1222 Clinical Trials Resumed in the UK, Statement on AstraZeneca Oxford SARS-CoV-2 Vaccine, AZD1222, COVID-19 Vaccine Trials Temporary Pause, AstraZenecas Scientific and Social Commitment for COVID-19 Vaccine AZD1222, Development of COVID-19 Vaccine AZD1222 Expands into US Phase III Clinical Trial Across All Adult Age Groups, AstraZeneca Australia & New Zealand Response to the COVID-19 Pandemic, AstraZeneca Concludes Agreement with the European Commission for the Supply of up to 400 Million Doses of AZD1222 COVID-19 Vaccine, COVID-19 Vaccine AZD1222 Showed Robust Immune Responses in All Participants in Phase I/II Trial, Cobra Signs Supply Agreement with AstraZeneca for Manufacture of COVID-19 Vaccine Candidate, AstraZeneca to Supply Europe With Up To 400 Million Doses of Oxford Universitys COVID-19 Vaccine At No Profit, AstraZeneca Takes Next Steps Towards Broad and Equitable Access to Oxford Universitys COVID-19 Vaccine, AstraZeneca Advances Response to Global COVID-19 Challenge as it Receives First Commitments for Oxfords Potential New Vaccine, Investigational ChAdOx1 nCoV-19 Vaccine Protects Monkeys Against COVID-19 Pneumonia, AstraZeneca and Oxford University Announce Landmark Agreement for COVID-19 Vaccine. startxref Electronic address . Dont include personal or financial information like your National Insurance number or credit card details. Your immune cells then recognise the spike protein as a threat and begin building an immune response against it. Ingredients in the Pfizer-BioNTech Comirnaty COVID-19 vaccine. The overall safety of COVID-19 Vaccine AstraZeneca is based on an interim analysis of pooled data from four clinical trials conducted in the United Kingdom, Brazil, and South Africa. This means that it is essentially 'sodium-free'.. The severity and intensity of local and systemic reactions was highest on day 1 after vaccination. endstream endobj 780 0 obj <. All 28 developed different types of clots, or thromboses, five to 16 days after vaccination, and all had made antibodies against platelets. By reporting side effects you can help provide more information on the safety of this vaccine. Available for Android and iOS devices. In the trial, 543 participants received AZD1222 (56 also received a prophylactic dose of the pain killer paracetamol), and 534 received MenACWY, a comparator meningococcal conjugate vaccine. A very rare adverse event called Thrombosis with Thrombocytopenia Syndrome (TTS), involving unusual and severe blood clotting events associated with low platelet counts, has been reported after vaccination with this vaccine. Epub 2020 Dec 8. Dont worry we wont send you spam or share your email address with anyone. Once it is approved for human research, there are three phases that take place before the vaccine can be considered for approval for public use. 0000083589 00000 n Like any vaccine, the COVID-19 vaccines do come with potential side effects. i; "32tBa;CC'd&@u^?^02/g`8Ea?U b t@f&!+:eez8YY8.j 7 However, a causal relationship with the vaccine has neither been confirmed nor ruled out and more rigorous studies are needed to fully assess the significance of &Va(f+0&+FIcDHoL 57 0 obj <> endobj xref See section 4. 0000005556 00000 n We use some essential cookies to make this website work. The shot gives the body instructions to create the spike protein from COVID-19 in its cells. AstraZeneca . Messenger RNA (mRNA) Nucleoside-modified mRNA encoding the viral spike (S) glycoprotein of SARS-CoV-2. You can help by reporting any side effects you may get. The need for, and timing of, booster doses for children aged 5-11 years has not yet been determined. Component. If you are concerned about a side-effect it can be reported directly via the Coronavirus Yellow Card reporting site or search for MHRA Yellow Card in the Google Play or Apple App Store and include the vaccine brand and batch/Lot number if available. What is the evidence for vaccine efficacy and safety in adults (18-59 years)? 0000009594 00000 n Unit dose strength (s) > 0.7 1011 vp/mL. It is designed for consumers and care givers. 0000098877 00000 n If you miss a scheduled injection, you may not be fully protected against COVID-19. a severe headache that is not relieved with simple painkillers or is getting worse or feels worse when you lie down or bend over, an unusual headache that may be accompanied by blurred vision, confusion, difficulty with speech, weakness, drowsiness or seizures (fits), rash that looks like small bruises or bleeding under the skin beyond the injection site, or any unexplained bleeding. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. $x >HdA@; Andrew Pollard was in a French taxi when he realised what was coming. After withdrawing the final dose, some liquid may remain in the vial. Some of the information might be out of date or no longer relevant. Preliminary findings highlight the urgent need for a coordinated approach for surveillance and evaluation of variants and their potential impact on vaccine effectiveness. s/s's?3on1;XX(@?<=f@(tv4;r% ~IX It causes the body to produce its own protection (antibodies) against the virus. WHO does not recommend pregnancy testing prior to vaccination. The Oxford-AstraZeneca vaccine contains no pork products or by-products. Attempts to develop an RSV vaccine began in the 1960s with an unsuccessful inactivated vaccine developed by exposing the RSV virus to formalin (formalin-inactivated RSV (FI-RSV)). ____________________________________________________________________________________. trailer <<082F7B1BF056430DB0F4C36E6FE6E521>]/Prev 207227>> startxref 0 %%EOF 96 0 obj <>stream Each vial contains 8 doses of 0.5 ml. At the time of analysis, 23,745 participants 18 years old had been randomised and received either COVID-19 Vaccine AstraZeneca or control. 0000011249 00000 n Vaccine Excipient Summary Excipients Included in U.S. , ,p This information was provided by the drug's manufacturer when this drug product was approved for sale in Canada. x 8) The AstraZeneca vaccine has been made from a modified adenovirus which causes the common cold in chimpanzees, but specifically modified so that it cannot cause an infection. syndrome [GBS]), rapid swelling under the skin in areas such as the face, lips, mouth and throat (which may cause difficulty in swallowing or breathing) (angioedema), capillary leak syndrome (a condition causing fluid leakage from small blood vessels), very low levels of blood platelets (immune thrombocytopenia) that can be associated with bleeding (see section 2, Blood disorders), blood clots in the brain, not associated with low level of blood platelets (see section 2, Blood disorders), inflammation of the spinal cord which may cause muscle weakness, localised or radiating back pain, bladder and bowel symptoms and changes in sensation (transverse myelitis). 0000107012 00000 n Such reactions may include a combination of any of the following symptoms: In clinical studies with the vaccine, fewer side effects were reported after the second dose and those that were reported were milder in nature when compared to after the first dose. Dosage level (s) 5 1010 vp (nominal). SAGE currently recommends its use according to the WHO Prioritization Roadmap, even if virus variants are present in a country. COVID-19 Vaccine AstraZeneca contains sodium and alcohol). Company: AstraZeneca 0000005016 00000 n 0000104953 00000 n 0000023338 00000 n 0000009792 00000 n To help pregnant women make this assessment, they should be provided with Organization: Public Health Agency of Canada. People under the age of 40 are to be offered an alternative to the Oxford-AstraZeneca vaccine in the UK as a precaution, after a review of all the latest evidence by vaccine advisers and safety . The Council for International Organizations of Medical Sciences classifies rates of adverse events or medicines and vaccines as follows: The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about (see section 2. Can they overcome their checkered past? You have rejected additional cookies. x]n@FwezA"+q*z B-csD"%;>3a,7Mg>;M1crUukGavi%. 0000006393 00000 n 0000010323 00000 n The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Side effects for many of the vaccines currently available for COVID-19 are similar, with injection site pain and soreness leading the most common reactions . In this vaccine ,polysorbate 80 works to separate the listed ingredient of water from other oil-based ingredients. Updated on 13 June 2022 to ensure consistency of formatting. After the first dose is withdrawn, the vaccine should be used as soon as practically possible and within 6 hours. JZD| WHO does not recommend discontinuing breastfeeding because of vaccination. If you are immunocompromised and receive a third dose of COVID-19 Vaccine AstraZeneca, it may still not provide full immunity to COVID-19 and you should continue to maintain physical precautions to help prevent COVID-19. The AstraZeneca COVID-19 vaccine, now called Vaxzevria, is a viral vector vaccine, just like the Johnson & Johnson vaccine. 410 0 obj <>stream It should be noted that the full two AstraZeneca's Oxford vaccine trial to resume, the university says The document, which is labeled an "initial report," describes how the study participant had trouble walking, weakness and pain. Of those who experienced fever, 18% reported temperatures of at least 38C, and 2% reported temperatures of at least 39C. 0000001596 00000 n This Oxford-AstraZeneca vaccine uses the ChAdOx1 technology, which has been developed and optimised by the Jenner Institute over the last 10 years. %PDF-1.6 % 0000006680 00000 n To view this licence, visit nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk. 0000008310 00000 n 0000003890 00000 n [recombinant]) [COVID-19 Vaccine AstraZeneca] with other vaccines have not been evaluated. Get urgent medical attention if you get symptoms of a severe allergic reaction. How COVID-19 Vaccine AstraZeneca is given 4. 0000098136 00000 n 0000103016 00000 n Title: Redirect for COVID-19 AstraZeneca Vaccine EUA Fact Sheet for Recipients Author: CDC/NCIRD Subject: The Oxford-AstraZeneca vaccine contains no thimerosal, mercury, or aluminum. WASHINGTON Workers at a plant in Baltimore manufacturing two coronavirus vaccines accidentally conflated the ingredients several weeks ago . Stabilizers, like L-histidine or sucrose, make sure the vaccine is able to stay effective during the times it is transported and stored.. any ingredients of COVISHIELD vaccine If you are breastfeeding If you are pregnant or plan to become pregnant WHAT YOU NEED TO KNOW BEFORE YOU GET THIS VACCINE Read this Fact Sheet for information about the COVISHIELD Vaccine. If you are not sure, talk to your doctor, pharmacist or nurse. Success! You may access the guidance document here. Tell your doctor, pharmacist or nurse if you are taking, have recently taken or might take, any other medicines or vaccines. Safety data sheet. 18 June 2021. It is important to remember the benefits of vaccination to give protection against COVID-19 still outweigh any potential risks. 0000006565 00000 n Netherlands. Guillain-Barr syndrome (GBS) has been reported very rarely following vaccination. hb```(1A;B% It is a proven, safe and relatively old approach. 55 0 obj The results confirmed a single dose of AZD1222 resulted in a four-fold increase in antibodies to the SARS-CoV-2 virus spike protein in 95% of participants one month after injection. Store in a refrigerator (2C to 8C). This is the same type of vaccine that flu and the Middle East Respiratory Syndrome vaccines have used for years. CoronaVac is an inactivated vaccine. Neutralising activity against SARS-CoV-2 (as assessed by the MNA80 assay) was seen in 91% of participants one month after vaccination and in 100% of participants who received a second dose. Tell your doctor, pharmacist or nurse before vaccination: If you are not sure if any of the above applies to you, talk to your doctor, pharmacist or nurse before you are given the vaccine. 0000001605 00000 n This type of vaccine technology has been tested for many other diseases such as influenza (flu) and middle east respiratory . It does not have a marketing authorisation, but this temporary authorisation grants permission for the medicine to be used for active immunisation of individuals aged 18 years and older for the prevention of coronavirus disease 2019 (COVID-19). It will take only 2 minutes to fill in. For countries considering heterologous schedules, WHO has made recommendations to ensure equivalent or favourable immunogenicity or vaccine effectiveness for heterologous versus homologous schedules: When considering booster vaccination after having been vaccinated with ChAdOx1-S [recombinant] COVID-19 [Astra Zeneca] vaccine for the primary series, SAGE considers using a different type of COVID-19 vaccine for a third dose a more favourable option. tenderness, pain, warmth, itching or bruising where the injection is given, swelling, redness or a lump at the injection site, flu-like symptoms, such as high temperature, sore throat, runny nose, cough and chills, sleepiness, feeling dizzy, or deep unresponsiveness and inactivity, excessive sweating, itchy skin, rash or hives. Possible side effects 5. 0000000016 00000 n The vaccine is not recommended for persons younger than 18 years of age pending the results of further studies. LqIai8O=,*EM~|>0: NiV|+'#M(FYQc`uic+)Gy1Q(:'4~0:,9Dbdf&. 0 SAGE has reviewed all available data on the performance of the vaccine in the settings of variants of concern. xref It's only capable of delivering the DNA," he said. Once this enters the body, it tells your cells to make copies of the spike protein. 0000009880 00000 n How to store COVID-19 Vaccine AstraZeneca 6. The Astra-Zeneca vaccine can be offered to people who have had COVID-19 in the past. Water dilutes the vaccine's ingredients, to make sure they are at the right level of concentration. AZD1222 (formerly ChAdOx1 nCoV-19) is an investigational vaccine against SARS-CoV-2 in development for the prevention of COVID-19. x]n@@eH%/Vu1]}sn\H6:ypen^mVU}m)QmB9ciMeT{ed#NtQwv/ ,6aYmk}*Oko8/q1(z h^ONc! are no data yet for Omicron. In line with the WHO Prioritization Roadmapand and the WHO Values Framework older adults, A respiratory syncytial virus vaccine or RSV vaccine is a vaccine which prevents infection by respiratory syncytial virus.As of 2023, no licensed vaccine against RSV exists.. AstraZeneca-Oxford vaccine was 76% effective at preventing symptomatic COVID-19 two weeks after the second dose and was 100% effective in stopping severe disease and hospitalization in a. 0000107040 00000 n hb```Y@(&(fL(aW$Xz$7 0000009283 00000 n Spills should be disinfected using agents with activity against adenovirus. hb```f``m ,@Q"12/L1T43xYsAC:?X\r()c .O8:g] l TB;]@< -ll`]@m EX Moderna bivalent COVID-19 vaccine. The AstraZeneca vaccine remains a safe and effective choice to protect against COVID-19, and will protect against severe outcomes from getting infected with COVID-19, including illness, hospitalization and death. If you have ever had a severe allergic reaction after any other vaccine injection or after you were given COVID-19 Vaccine AstraZeneca in the past. A Phase I/II clinical trial commenced on April 23, 2020 to assess the safety, immunogenicity and efficacy of AZD1222 in 1077 healthy volunteers aged 18 to 55 years across several trial centres in southern England. 3. This included some severe cases with blood clots in different or unusual locations and excessive clotting or bleeding throughout the body. Additional Information If you have questions, visit the website or call the telephone number provided The Oxford-AstraZeneca vaccine is cheaper and easier to transport and store than some of the other vaccines approved for use to date and as such, was going to play a key part in combating the . Older people have been prioritized to receive COVID-19 vaccines in many areas of the world. %PDF-1.7 0000053643 00000 n Vaccine AstraZeneca in children and adolescents younger than 18 years of age. Vaccines, by Vaccine In addition to weakened or killed disease antigens (such as weakened, killed, or parts of viruses or bacteria), vaccines contain very small amounts of other ingredients - excipients. 0000098057 00000 n A booster dose may be considered 4 6 months after completion of the primary vaccination series, starting with the higher priority-use groups, in accordance with the WHO Prioritization Roadmap. Preservatives in this vaccine are disodium edetate dihydrate and ethanol. hbbd```b``3@$1dYL`)`5w. To help us improve GOV.UK, wed like to know more about your visit today. 0000085176 00000 n Vaccines are generally very safe and their study involves a rigorous process. The majority of recipients were White (75.5%), 10.1% were Black and 3.5% were Asian; 55.8% were female and 44.2% male. Wed like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. 0000004413 00000 n k [ What COVID-19 Vaccine AstraZeneca is and what it is used for, What you need to know before you are given COVID-19 Vaccine AstraZeneca, How COVID-19 Vaccine AstraZeneca is given, How to store COVID-19 Vaccine AstraZeneca, Contents of the pack and other information, Check benefits and financial support you can get, Find out about the Energy Bills Support Scheme, Regulatory approval of COVID-19 Vaccine AstraZeneca, Package leaflet: Information for the recipient, nationalarchives.gov.uk/doc/open-government-licence/version/3. Moderna COVID-19 vaccine. Adenoviruses are a common group of viruses that cause different types of sicknesses like bronchitis. However, a mild fever or infection, like a cold, are not reasons to delay vaccination; If you have ever had a condition known as heparin-induced thrombocytopenia and thrombosis (HITT or HIT type 2), or a blood clot in the sinus veins in the brain; If you have a problem with bleeding or bruising, or if you are taking a blood thinning medicine (anticoagulant); If your immune system does not work properly (immunodeficiency) or you are taking medicines that weaken the immune system (such as high-dose corticosteroids, immunosuppressants or cancer medicines). 2021 Jan 9;397(10269):72-74. doi: 10.1016/S0140-6736(20)32623-4. 0000012193 00000 n COVID-19 Vaccine AstraZeneca is a vaccine used for preventing COVID 19, caused by a virus called coronavirus (SARS-CoV-2). . This explainer is more than 90 days old. As of May 2022, people over age 5 are eligible to receive an FDA-approved COVID-19 vaccine.For booster shots, the CDC recommendation is that you should be older than 5 years of age. 0000006540 00000 n 0000008003 00000 n This medicine contains a very small amount of alcohol (2 mg of alcohol (ethanol) per dose of 0.5 ml). The first ingredient on the listthe weakened adenovirusis the active ingredient in this vaccine. Vaccines are tested and studied in multiple phases (phased testing) to determine if they are safe and work to prevent illness. AstraZeneca's vaccine contains a chimpanzee adenovirus genetically engineered to avoid its replication and instead make Covid spike protein in people receiving the jab. The Astra Zeneca vaccine remains a suitable option as a heterologous booster to primary series vaccination with a different vaccine. 548 0 obj <> endobj It has been adjusted to work as a delivery system for the vaccine. However, it is not confirmed whether these events were due to the vaccine. 870 0 obj <>stream 0000015573 00000 n %PDF-1.7 % The AstraZeneca vaccine is safe and effective at protecting people from the extremely serious risks of COVID-19, including death, hospitalization and severe disease. 346 0 obj <> endobj We comply with the HONcode standard for trustworthy health information. endstream endobj 76 0 obj <> stream Neither Pfizer nor Moderna . None of the ingredients in this vaccine can cause COVID-19. Information about the Moderna bivalent coronavirus vaccine, including vaccine ingredients, is available: . 0000002028 00000 n Browse our homepage for up to date content or request information about a specific topic from our team of scientists. Much to everyone's surprise, the experimental mRNA vaccines are most effective (95%), while the time-tested adenoviral vector . 4.6 Fertility, pregnancy and lactation Pregnancy There is a limited amount of data from the use of COVID-19 Vaccine (ChAdOx1-S [recombinant]) [COVID-19 Vaccine AstraZeneca] in pregnant women, or women who became pregnant after receiving the vaccine. Known to be a potential allergen. Interim results were published in. 0000013285 00000 n If you feel unwell after vaccination, do not drive or use machines. November 2020 - Trial data dispute. If you forget to go back at the scheduled time, ask your doctor, pharmacist or nurse for advice. % These ingredients range from forms of salt that help preserve the vaccine to water that dilutes it into the right concentration. hb``g``oc`c` @1v=k}u F'SUNZ AstraZeneca is a member of Covax, a global initiative aiming to distribute two billion vaccine doses to 92 low- and middle-income countries at no more than $3 a dose. 0000055209 00000 n dose regimen of this vaccine is believed to be more protective against variants of concern than a single dose alone. xVN@}W#E{I HTJB+!`)m;:KQyX99se AstraZeneca published an interim analysis of clinical trials showing that its Covid vaccine had an average efficacy of 70% in protecting against the virus . Efficacy. Like all medicines, this vaccine can cause side effects, although not everybody gets them. The majority of these cases occurred within the first four weeks following vaccination. When COVID-19 Vaccine AstraZeneca is given for the first injection, the second injection to complete the vaccination course should also be with COVID-19 Vaccine AstraZeneca. If you miss an appointment for your second injection of COVID-19 Vaccine AstraZeneca 0000018147 00000 n Following widespread use of the vaccine there have been extremely rare reports of blood clots in combination with low level of blood platelets. endstream It is a summary of information about the drug and will not tell you everything about the drug. 0000006047 00000 n 57 40 0000097826 00000 n or call 1-800-FDA-1088 or call AstraZeneca at 1-800-236-9933. 0000093171 00000 n /ID [<46442D36362D36432D33412D43412D36>] See the end of section 4 for how to report side effects. Late-stage Phase II/III trials were conducted in the UK, Brazil, South Africa and the US. 6. Statement of the WHO Global Advisory Committee on Vaccine Safety (GACVS) COVID-19 subcommittee on safety signals related to the AstraZeneca COVID-19 vaccine, Interim statement of the COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on AstraZeneca COVID-19 vaccine, The Janssen Ad26.COV2.S COVID-19 vaccine: What you need to know, The Moderna COVID-19 (mRNA-1273) vaccine: what you need to know, The Pfizer BioNTech (BNT162b2) COVID-19 vaccine: What you need to know, The Sinovac-CoronaVac COVID-19 vaccine: What you need to know, The Sinopharm COVID-19 vaccine: What you need to know, The Novavax vaccine against COVID-19: What you need to know, The Bharat Biotech BBV152 COVAXIN vaccine against COVID-19: What you need to know, Independent Oversight and Advisory Committee, WHO Strategic Advisory Group of Experts on Immunization (SAGE), Strategic Advisory Group of Experts on Immunization, Interim recommendations for use of the ChAdOx1-S [recombinant] vaccine against COVID-19 (AstraZeneca COVID-19 vaccine AZD1222 Vaxzevria, SII COVISHIELD), The Oxford/AstraZeneca (ChAdOx1-S [recombinant] vaccine) COVID-19 vaccine: what you need to know, Uncommon (infrequent) >1/1000 and < 1/100, The Astra-Zeneca vaccine recommendations have also been modified to indicate that either of the mRNA COVID-19 vaccines (Pfizer or Moderna) can be used as a second dose following a, The Astra-Zeneca vaccine can be used as a. 0000015344 00000 n 0000004537 00000 n Contents of the pack and other information 1. 0000003465 00000 n 56 0 obj EVIDENCE ASSESSMENT: BBIBP COVID-19 vaccine (BBIBP-CorV) Key evidence to inform policy recommendations on the use of BBIBP-CorV The SAGE Working Group specifically considered the following questions: 1. As with any new medicine in the UK this product will be closely monitored to allow quick identification of new safety information. It is important that you return for your second injection of COVID-19 Vaccine AstraZeneca. A nurse prepares a vial with AstraZeneca's vaccine against the coronavirus (Covid-19) at a doctor's office in Deisenhofen, southern Germany, on March 31, 2021, amid the ongoing pandemic. The human protein impurities - mostly heat shock and cell scaffold proteins - come from the human kidney cell line used to generate the chimp adenovirus. hb```b``9 |Abl,=@00M(P~. "A Simple Breakdown of the Ingredients in the COVID Vaccines." 11 Jan 2021. Consumer Information. Solution for injection. 0 COVID-19 Vaccine (ChAdOx1 S [recombinant]). The AstraZeneca vaccine does contain polysorbate. 6`CA$'i$W30120ma`$p@ J <>/Metadata 30 0 R>> Well send you a link to a feedback form. Some people have reported a sudden feeling of cold with shivering/shaking accompanied by a rise in temperature, possibly with sweating, headache (including migraine-like headaches), nausea, muscle aches and feeling unwell, starting within a day of having the vaccine and usually lasting for a day or two. 3.What if I am taking, have recently taken or might take other medicinesor News stories, speeches, letters and notices, Reports, analysis and official statistics, Data, Freedom of Information releases and corporate reports. 0000015637 00000 n Systemic reactions were common in the AZD1222 without paracetamol group, with 340 (70%) reporting fatigue and 31 (68%) reporting headache. For the Oxford-AstraZeneca vaccine, 30 cases of anaphylaxis have been confirmed . xc```b``g`a```d@ A+s4@s60J:Up95PA? << /Type /XRef /Filter /FlateDecode /Length 115 /W [ 1 3 1 ] /Index [ 53 36 ] The AstraZeneca vaccine uses a harmless, weakened animal virus (called a viral vector) that contains the genetic code for the coronavirus spike protein. WHO recommends the use of the ChAdOx1-S [recombinant] COVID-19 vaccine in pregnant women only when the benefits of vaccination to the pregnant woman outweigh the potential risks. Information might be out of date or no longer relevant National Insurance number or credit card details and. You everything about the drug and will not tell you everything about the Moderna bivalent vaccine! For children aged 5-11 years has not yet been determined Jan 2021 doses children! Updated on 13 June 2022 to ensure consistency of formatting has reviewed all available data on safety. ( 20 ) 32623-4 older people have been prioritized to receive COVID-19 vaccines do with... Number or credit card details standard for trustworthy health information been prioritized to receive vaccines. Experienced fever, 18 % reported temperatures of at least 39C with anyone called Vaxzevria, is a summary information! Unwell after vaccination effects, although not everybody gets them are a common group viruses! Discontinuing breastfeeding because of vaccination AstraZeneca at 1-800-236-9933 gives the body instructions to create the spike.! 5 1010 vp ( nominal ) with potential side effects with any new medicine in COVID. Performance of the information might be out of date or no longer relevant prevent illness trustworthy information. Medical attention if you are not sure, talk to your doctor, pharmacist or nurse for advice 18 reported... ):72-74. doi: 10.1016/S0140-6736 ( 20 ) 32623-4 ; a Simple Breakdown of pack! Cookies astrazeneca vaccine ingredients pdf make copies of the ingredients in this vaccine are disodium edetate and... Dose is withdrawn, the COVID-19 vaccines do come with potential side effects you can by... Feel unwell after vaccination, do not drive or use machines important that you return for your injection. Astrazeneca or control he realised what was coming vaccine AstraZeneca in children and adolescents than... Means that it is a summary of information about the drug vaccine should used... It has been reported very rarely following vaccination is important to remember the benefits of.... N you can not usually choose which vaccine you have minutes to fill in be closely monitored to quick! This is the evidence for vaccine efficacy and safety in adults ( 18-59 years ) cells recognise. N Contents of the spike protein as a heterologous booster to primary series vaccination with a vaccine... 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